A-419259
A-419259 (RK-20449) is a potent and selective small molecule inhibitor of Src-family kinases (SFKs), such as Src, LCK, and Lyn, with IC50 values in the low nanomolar range (3-9 nM) . This apoptosis-inducing compound is a valuable research tool for studying SFK signaling in oncology and immunology, with applications in both in vitro cellular assays and in vivo model systems.
Product Specifications
CAS Number
364042-47-7
Product Name Alternative
Src, RK20449, RK-20449, RK 20449, A 419259, Abl, A-419259, A419259, Lck, Lyn
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.48% (May vary between batches)
Solubility
H2O:< 0.1 mg/mL (insoluble) ; DMSO:10 mg/mL (20.72 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.07 mM)
Smiles
NC1=C2C (=CN (C2=NC=N1) [C@H]3CC[C@@H] (CC3) N4CCN (C) CC4) C5=CC=C (OC6=CC=CC=C6) C=C5
Molecular Formula
C29H34N6O
Molecular Weight
482.62
Storage Conditions
-20°C
Notes
For research use only.
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