A-9758
A-9758 is a potent and selective RORγt inverse agonist (IC50 = 5 nM) that effectively inhibits IL-17A release. It suppresses Th17 cell differentiation and function, and has demonstrated efficacy in reducing psoriasiform skin inflammation in an IL-23-driven in vivo model.
Product Specifications
CAS Number
2055271-22-0
Field of Research
Immunology & Inflammation, Metabolism Research
Smiles
CN1C=2C (C=C1CC3=C (Cl) C (C (=O) N4CCC (C (O) =O) CC4) =CC=C3Cl) =C (C) C=C (C (F) (F) F) C2
Molecular Formula
C25H23Cl2F3N2O3
Molecular Weight
527.36
Storage Conditions
-20°C
Notes
For research use only.
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