A-437203
A-437203 (Lu201640) is a novel, potent, and selective dopamine D3 receptor antagonist based on a 1H-pyrimidin-2-one scaffold, exhibiting Ki values of 71 nM, 1.6 nM, and 6220 nM for D2, D3, and D4 receptors, respectively. This compound is a valuable pharmacological tool for in vitro and in vivo research into disorders involving dopaminergic signaling, such as addiction and Parkinson's disease.
Product Specifications
CAS Number
220519-06-2
Product Name Alternative
Dopamine Receptor, DopamineReceptor, D2 receptor, D3 receptor, D4 receptor, ABT925, ABT-925, ABT 925, A 437203, A 37203, A37203, A-37203, A437203, A-437203, Lu201640
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.62% (May vary between batches)
Solubility
DMSO:60 mg/mL (131.43 mM)
Smiles
C (F) (F) (F) C1=CC (=NC (C (C) (C) C) =N1) N2CCN (CCCSC=3NC (=O) C=CN3) CC2
Molecular Formula
C20H27F3N6OS
Molecular Weight
456.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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