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A-437203

A-437203 (Lu201640) is a novel, potent, and selective dopamine D3 receptor antagonist based on a 1H-pyrimidin-2-one scaffold, exhibiting Ki values of 71 nM, 1.6 nM, and 6220 nM for D2, D3, and D4 receptors, respectively. This compound is a valuable pharmacological tool for in vitro and in vivo research into disorders involving dopaminergic signaling, such as addiction and Parkinson's disease.

Product Specifications

CAS Number

220519-06-2

Product Name Alternative

Dopamine Receptor, DopamineReceptor, D2 receptor, D3 receptor, D4 receptor, ABT925, ABT-925, ABT 925, A 437203, A 37203, A37203, A-37203, A437203, A-437203, Lu201640

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Purity

98.62% (May vary between batches)

Solubility

DMSO:60 mg/mL (131.43 mM)

Smiles

C (F) (F) (F) C1=CC (=NC (C (C) (C) C) =N1) N2CCN (CCCSC=3NC (=O) C=CN3) CC2

Molecular Formula

C20H27F3N6OS

Molecular Weight

456.53

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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