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AHR antagonist 5

AHR antagonist 5 (Example 39) is a potent, orally bioavailable aryl hydrocarbon receptor inhibitor with an IC50 below 0.5 μM. It demonstrates significant in vivo antitumor efficacy in combination with anti-PD-1 checkpoint blockade, making it a valuable research tool for immuno-oncology studies.

Product Specifications

CAS Number

2247953-39-3

Field of Research

Immunology & Inflammation, Pharmacology & Drug Discovery

Smiles

Cl.Cl.Cl.CC (C) c1cnn2c (N[C@@H]3CCc4[nH]c5ccccc5c4C3) nc (nc12) -c1cncc (F) c1

Molecular Formula

C25H27Cl3FN7

Molecular Weight

550.89

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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