ALK2-IN-2
ALK2-IN-2 is a highly selective small molecule inhibitor of activin receptor-like kinase 2 (ALK2), demonstrating potent activity with an IC50 of 9 nM and exhibiting over 700-fold selectivity against ALK3. This inhibitor is a valuable chemical probe for studying BMP signaling in fibrodysplasia ossificans progressiva (FOP) and other disorders, supporting both in vitro biochemical assays and in vivo disease model research.
Product Specifications
CAS Number
2254409-25-9
Product Name Alternative
TGFb, TGF-b/Smad, TGFbeta, TGF-beta, TGFbeta/Smad, Smad, TGF-β Receptor, TGF-β/Smad, TGFβ, ALK3, ALK2, ALK2 IN 2, ALK2IN2, ALK-2-IN-2, ALK2-IN-2
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.55% (May vary between batches)
Solubility
DMSO:112.5 mg/mL (226.08 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.04 mM)
Smiles
CC (N1CCCC1) c1ccc (cc1) -c1cnc2c (cnn2c1) -c1ccc (c2ccccc12) S (N) (=O) =O
Molecular Formula
C28H27N5O2S
Molecular Weight
497.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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