AM-6494
AM-6494 is a potent, orally bioavailable small molecule inhibitor that selectively targets BACE1 over BACE2, with IC50 values of 0.4 nM and 18.6 nM, respectively. It is a valuable research tool for investigating BACE1 function in Alzheimer's disease pathogenesis through both in vitro enzymatic assays and in vivo model studies.
Product Specifications
CAS Number
1874232-80-0
Field of Research
Neuroscience
Smiles
C (OC) [C@]12[C@] ([C@] (C) (N=C (N) S1) C3=CC (NC (=O) C=4C=NC (OCC#C) =CN4) =CC (F) =C3F) (C2) [H]
Molecular Formula
C22H21F2N5O3S
Molecular Weight
473.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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