Androgen receptor antagonist 1
This orally bioavailable, potent androgen receptor (AR) full antagonist (IC50 = 59 nM) serves as a versatile chemical tool for prostate cancer research. It effectively inhibits AR signaling and can be utilized as a precursor for synthesizing PROTAC degraders, which have demonstrated significant AR protein knockdown in LNCaP cell-based studies.
Product Specifications
CAS Number
1338812-36-4
Product Name Alternative
Androgen receptor
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.05% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (7.92 mM) ; DMSO:80 mg/mL (191.89 mM)
Smiles
CC1 (C) [C@H] (NC (=O) c2cnn (CCO) c2) C (C) (C) [C@H]1Oc1ccc (C#N) c (Cl) c1
Molecular Formula
C21H25ClN4O3
Molecular Weight
416.9
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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