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AS2863619 free base

AS2863619 free base is a potent, orally bioavailable inhibitor of CDK8 and CDK19 that promotes the differentiation of antigen-specific T cells into Foxp3+ regulatory T cells. This conversion is mediated through enhanced STAT5 activation and subsequent Foxp3 gene induction, making it a valuable tool for studying immune tolerance in both in vitro and in vivo models.

Product Specifications

CAS Number

2241300-50-3

Field of Research

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Smiles

Cc1nc2ccc (cc2[nH]1) -n1c (nc2cnccc12) -c1nonc1N

Molecular Formula

C16H12N8O

Molecular Weight

332.32

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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