ATM Inhibitor-1
ATM Inhibitor-1 is a potent, selective, and orally bioavailable small molecule inhibitor of ATM kinase with an IC50 of 0.7 nM. It demonstrates significant anti-tumor activity in preclinical models and exhibits high selectivity over related kinases like mTOR, DNA-PK, and PI3K isoforms. This compound is a valuable chemical probe for investigating DNA damage response pathways in cancer research, both in vitro and in vivo.
Product Specifications
CAS Number
2135639-94-8
Field of Research
Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
N ([C@@H] (C) C1CCOCC1) C=2C3=C (N=NC2C (NC) =O) C=CC (=C3) C=4C=CC (OCCCN (C) C) =NC4
Molecular Formula
C27H36N6O3
Molecular Weight
492.61
Storage Conditions
-20°C
Notes
For research use only.
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