AZ12601011
AZ12601011 is a potent, selective, and orally bioavailable TGF-β receptor 1 (TGFBR1) kinase inhibitor. It binds directly to TGFBR1, blocking Smad3 signaling, which underlies its demonstrated activity in reducing inflammatory cytokine release and inhibiting tumor growth in breast cancer models, as well as its potential in preventing renal fibrosis.
Product Specifications
CAS Number
2748337-86-0
Product Name Alternative
ALK4, AZ 12601011, AZ12601011, AZ-12601011, TGF-b/Smad, TGFb, TGF-beta, TGFbeta, TGFbeta/Smad, TGFBR1, Smad, TGF-β/Smad, TGFβR1, TGFβ
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.81% (May vary between batches)
Solubility
DMSO:4 mg/mL (12.76 mM)
Smiles
N=1C=CC2=C (C1) C=CN2C3=NC (=NC4=C3CCC4) C5=NC=CC=C5
Molecular Formula
C19H15N5
Molecular Weight
313.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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