Aβ42-IN-1 free base
Aβ42-IN-1 free base is an orally bioavailable γ-secretase modulator that potently reduces Aβ42 levels in vitro (IC50 = 0.091 μM) and demonstrates significant brain exposure and efficacy in lowering brain Aβ42 in mouse models. This profile supports its investigation as a potential therapeutic agent for Alzheimer's disease research.
Product Specifications
CAS Number
2434633-17-5
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Smiles
CC1=C (N2C (=N1) C (OCC3=CC=C (C=C3) C4=CC=CC=C4) =CC=C2) C=5C=CC (C (NCC) =O) =NC5
Molecular Formula
C29H26N4O2
Molecular Weight
462.54
Storage Conditions
-20°C
Notes
For research use only.
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