BACE1-IN-5
BACE1-IN-5 (Compound 15) is a potent small molecule inhibitor of BACE1, exhibiting an IC50 of 9.1 nM against the enzyme and 0.82 nM in cellular Aβ reduction assays. Its optimized profile includes considerations for hERG and P-gp, making it a valuable chemical probe for Alzheimer's disease research in both biochemical and cell-based studies.
Product Specifications
CAS Number
2581114-83-0
Field of Research
Cell Biology, Neuroscience
Smiles
C[C@]1 (C[C@@H] (C (F) (F) F) SC (N) =N1) C2=CC (NC (=O) C=3C=NC (OCF) =CN3) =CC=C2F
Molecular Formula
C18H16F5N5O2S
Molecular Weight
461.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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