Lisaftoclax
Lisaftoclax is an orally bioavailable small molecule that potently inhibits the anti-apoptotic proteins Bcl-2 (IC50=2 nM) and Bcl-xL (IC50=5.9 nM) . It is used in research for chronic lymphocytic leukemia (CLL), demonstrating pro-apoptotic activity in both cellular assays and in vivo models.
Product Specifications
CAS Number
2180923-05-9
Product Name Alternative
Lisaftoclax, APG2575, APG-2575, APG 2575, Bcl-xL, Bcl-2, Bcl-2/Bcl-xl inhibitor 1
Field of Research
Cell Biology
Purity
97.14% (May vary between batches)
Solubility
DMSO:45 mg/mL (51 mM)
Smiles
[O-][N+] (=O) c1cc (ccc1NC[C@H]1COCCO1) S (=O) (=O) NC (=O) c1ccc (cc1Oc1cnc2[nH]ccc2c1) N1CCN (CC2=C (CC3 (CCC3) CC2) c2ccc (Cl) cc2) CC1
Molecular Formula
C45H48ClN7O8S
Molecular Weight
882.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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