BCR-ABL-IN-2
BCR-ABL-IN-2 is a potent small molecule inhibitor targeting the BCR-ABL1 kinase, with IC50 values of 57 nM for the native protein and 773 nM for the T315I mutant. It serves as a valuable research tool for in vitro studies of chronic myeloid leukemia (CML) and drug resistance mechanisms.
Product Specifications
CAS Number
897369-18-5
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N (C (NC1=C (Cl) C (Cl) =CC=C1) =O) C=2N (N=C (C (C) (C) C) C2) C=3C=C4C (=CC3) CN[C@H] (C (O) =O) C4
Molecular Formula
C24H25Cl2N5O3
Molecular Weight
502.39
Storage Conditions
-20°C
Notes
For research use only.
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