Pamidronate (disodium)

Pamidronate disodium (CGP 23339A), the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma[1][2][3][4].

Product Specifications

CAS Number

[57248-88-1]

Product Name Alternative

CGP 23339A

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

RANKL/RANK ; Toll-like Receptor (TLR) ; Wnt; β-catenin

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pamidronate-disodium.html

Purity

98.0

Solubility

H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OP(C(O)(P(O)(O[Na])=O)CCN)(O[Na])=O

Molecular Formula

C3H9NNa2O7P2

Molecular Weight

279.03

Precautions

H302, H315, H319, H335

References & Citations

[1]Ashton JA, et al. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cellsfrom dogs. Am J Vet Res. 2005 May;66 (5) :885-91.|[2]Xu Y, et al. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017 Mar 22.|[3]Lv Y, et al. Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits. BMC Musculoskelet Disord. 2014 Nov 6;15:370.|[4]Kovacs R, et al. The synthesis of pamidronic derivatives in different solvents: An optimization and a mechanistic study[J]. Heteroatom Chemistry, 2014, 25 (3) : 186-193.