Numidargistat dihydrochloride
Numidargistat dihydrochloride (CB-1158 dihydrochloride) is an orally bioavailable, potent arginase 1 (ARG1) inhibitor used in immuno-oncology research. It has been shown in vitro and in vivo to inhibit TGF-β2-induced cataractogenesis by suppressing lens epithelial cell proliferation and reducing markers of fibrosis like fibronectin and α-SMA.
Product Specifications
Product Name Alternative
INCB 01158, INCB 01158 dihydrochloride, INCB01158, INCB-01158, INCB01158 dihydrochloride, INCB-01158 Dihydrochloride, Arginase 1, Arginase 2, 2095732-06-0, 2095732-06-0 free base, CB1158, CB 1158, CB 1158 Dihydrochloride, CB 1158 dihydrochloride (2095732 06 0 free base), CB-1158, CB1158 dihydrochloride, CB-1158 dihydrochloride, CB-1158 dihydrochloride (free base), CB1158 dihydrochloride (2095732060 free base)
Field of Research
Immunology & Inflammation
Purity
99.49% (May vary between batches)
Solubility
H2O:30 mg/mL (83.32 mM) ; DMSO:40 mg/mL (111.1 mM)
Smiles
O=C ([C@@H] (N) C) N1C[C@H] (CCCB (O) O) [C@] (N) (C (O) =O) C1.Cl.Cl
Molecular Formula
C11H24BCl2N3O5
Molecular Weight
360.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K1107106 1.0 µg DNA
ITM2BP sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 
K7191102 1.0 µg DNA
Slc16a2 sgRNA CRISPR Lentivector (Rat) (Target 1)
Sign In for Pricing
View Details 
LV785055 1.0 µg DNA
RPS29P22 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)
Sign In for Pricing
View Details