Numidargistat dihydrochloride
Numidargistat dihydrochloride (CB-1158 dihydrochloride) is an orally bioavailable, potent arginase 1 (ARG1) inhibitor used in immuno-oncology research. It has been shown in vitro and in vivo to inhibit TGF-β2-induced cataractogenesis by suppressing lens epithelial cell proliferation and reducing markers of fibrosis like fibronectin and α-SMA.
Product Specifications
Product Name Alternative
INCB 01158, INCB 01158 dihydrochloride, INCB01158, INCB-01158, INCB01158 dihydrochloride, INCB-01158 Dihydrochloride, Arginase 1, Arginase 2, 2095732-06-0, 2095732-06-0 free base, CB1158, CB 1158, CB 1158 Dihydrochloride, CB 1158 dihydrochloride (2095732 06 0 free base), CB-1158, CB1158 dihydrochloride, CB-1158 dihydrochloride, CB-1158 dihydrochloride (free base), CB1158 dihydrochloride (2095732060 free base)
Field of Research
Immunology & Inflammation
Purity
99.49% (May vary between batches)
Solubility
H2O:30 mg/mL (83.32 mM) ; DMSO:40 mg/mL (111.1 mM)
Smiles
O=C ([C@@H] (N) C) N1C[C@H] (CCCB (O) O) [C@] (N) (C (O) =O) C1.Cl.Cl
Molecular Formula
C11H24BCl2N3O5
Molecular Weight
360.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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