CCR1 antagonist 9
This potent and selective aziridine-based CCR1 antagonist (compound 19e) demonstrates an IC50 of 6.8 nM in calcium flux assays with significantly reduced hERG activity (IC50 = 30 μM) . It is a valuable research tool for investigating CCR1-mediated pathways in inflammatory and autoimmune diseases using in vitro and in vivo models.
Product Specifications
CAS Number
1220026-26-5
Product Name Alternative
CCR1, CCR1 antagonist 9, CCR-1 antagonist 9
Field of Research
Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery, Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
99.13% (May vary between batches)
Solubility
DMSO:64 mg/mL (150.43 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (5.88 mM)
Smiles
O=C (NCC=1C=CN=C (C1) S (=O) (=O) C) C2=CN=CC3=C2C=NN3C4=CC=C (F) C=C4
Molecular Formula
C20H16FN5O3S
Molecular Weight
425.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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