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CCR7 Ligand 1

CCR7 Ligand 1 (CCR7-Cmp2105) is a potent allosteric antagonist of human CCR7 with a 3 nM Kd. This thiadiazole-dioxide ligand inhibits CCL19-induced arrestin recruitment (IC50 = 7.3 μM) . It serves as a key research tool for investigating CCR7-mediated immune cell migration and lymph node biology in both cellular and animal models.

Product Specifications

CAS Number

681514-83-0

Field of Research

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Smiles

CN (C) C (=O) c1c (C) ccc (NC2=NS (=O) (=O) N=C2N[C@@H] (c2ccc (C) o2) C (C) (C) C) c1O

Molecular Formula

C22H29N5O5S

Molecular Weight

475.56

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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