CDK8/19-IN-1

CDK8/19-IN-1 is a potent, selective, and orally bioavailable dual inhibitor of CDK8 and CDK19, with IC50 values of 0.46 nM and 0.99 nM, respectively. It is a valuable research tool for studying the Mediator complex in oncology and inflammation, enabling both in vitro biochemical assays and in vivo model studies.