Cot inhibitor-1
Cot inhibitor-1 is a potent and selective small molecule targeting the Cot/Tpl2 (MAP3K8) kinase, exhibiting an IC50 of 28 nM. It effectively suppresses TNF-α production in human whole blood (IC50 = 5.7 nM), supporting its research utility in studying inflammatory pathways, immune responses, and related conditions such as rheumatoid arthritis and inflammatory bowel disease.
Product Specifications
CAS Number
915365-57-0
Product Name Alternative
TNF-α, Cot inhibitor 1, Cot inhibitor1, Cot inhibitor-1, MAP3K
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.59% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.61 mM) ; DMSO:55 mg/mL (99.37 mM) ; H2O:0.1 mg/mL (0.18 mM)
Smiles
Fc1ccc (Nc2c (cnc3c (Cl) cc (NCc4cn (CCN5CCCCCC5) nn4) cc23) C#N) cc1Cl
Molecular Formula
C27H27Cl2FN8
Molecular Weight
553.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Nsf (Vesicle-fusing ATPase, N-ethylmaleimide-sensitive Fusion Protein, NEM-sensitive Fusion Protein, Vesicular-fusion Protein NSF, Protein SKD2, Skd2) discontinued