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Cot inhibitor-1 hydrochloride

Cot inhibitor-1 hydrochloride is a potent and selective small molecule inhibitor of TPL2 kinase (IC50 = 28 nM) . It effectively suppresses TNF-α production in human whole blood assays (IC50 = 5.7 nM), making it a valuable research tool for studying inflammation and oncology pathways in cellular models.

Product Specifications

Product Name Alternative

TNF-α, MAP3K, Cot inhibitor-1 Hydrochloride, Cot inhibitor-1 hydrochloride (915365-57-0 Free base)

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.26% (May vary between batches)

Solubility

DMSO:50 mg/mL (84.76 mM)

Smiles

N#CC1=CN=C2C (Cl) =CC (NCC3=CN (CCN4CCCCCC4) N=N3) =CC2=C1NC5=CC=C (C (Cl) =C5) F.Cl

Molecular Formula

C27H28Cl3FN8

Molecular Weight

589.92

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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