Cot inhibitor-1 hydrochloride
Cot inhibitor-1 hydrochloride is a potent and selective small molecule inhibitor of TPL2 kinase (IC50 = 28 nM) . It effectively suppresses TNF-α production in human whole blood assays (IC50 = 5.7 nM), making it a valuable research tool for studying inflammation and oncology pathways in cellular models.
Product Specifications
Product Name Alternative
TNF-α, MAP3K, Cot inhibitor-1 Hydrochloride, Cot inhibitor-1 hydrochloride (915365-57-0 Free base)
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.26% (May vary between batches)
Solubility
DMSO:50 mg/mL (84.76 mM)
Smiles
N#CC1=CN=C2C (Cl) =CC (NCC3=CN (CCN4CCCCCC4) N=N3) =CC2=C1NC5=CC=C (C (Cl) =C5) F.Cl
Molecular Formula
C27H28Cl3FN8
Molecular Weight
589.92
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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