Cot inhibitor-1 hydrochloride
Cot inhibitor-1 hydrochloride is a potent and selective small molecule inhibitor of TPL2 kinase (IC50 = 28 nM) . It effectively suppresses TNF-α production in human whole blood assays (IC50 = 5.7 nM), making it a valuable research tool for studying inflammation and oncology pathways in cellular models.
Product Specifications
Product Name Alternative
TNF-α, MAP3K, Cot inhibitor-1 Hydrochloride, Cot inhibitor-1 hydrochloride (915365-57-0 Free base)
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.26% (May vary between batches)
Solubility
DMSO:50 mg/mL (84.76 mM)
Smiles
N#CC1=CN=C2C (Cl) =CC (NCC3=CN (CCN4CCCCCC4) N=N3) =CC2=C1NC5=CC=C (C (Cl) =C5) F.Cl
Molecular Formula
C27H28Cl3FN8
Molecular Weight
589.92
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
AE22305HU-01 48 Tests
Human Regulator of G-protein signaling 2 (RGS2) ELISA Kit
Sign In for Pricing
View Details AE22305HU-02 96 Tests
Human Regulator of G-protein signaling 2 (RGS2) ELISA Kit
Sign In for Pricing
View Details 
MBS6467826-01 0.1 mL
CNOT4, NT (E3 Ubiquitin-protein Ligase CNOT4, CCR4-associated Factor 4, Potential Transcriptional Repressor NOT4Hp, CCR4-NOT Transcription Complex Subunit 4, NOT4) (MaxLight 650)
Sign In for Pricing
View Details MBS6467826-02 5x 0.1 mL
CNOT4, NT (E3 Ubiquitin-protein Ligase CNOT4, CCR4-associated Factor 4, Potential Transcriptional Repressor NOT4Hp, CCR4-NOT Transcription Complex Subunit 4, NOT4) (MaxLight 650)
Sign In for Pricing
View Details 374658-01 20 µg
PEA15, Recombinant, Human, aa1-130, GST-Tag (Astrocytic Phosphoprotein PEA-15)
Sign In for Pricing
View Details 374658-02 100 µg
PEA15, Recombinant, Human, aa1-130, GST-Tag (Astrocytic Phosphoprotein PEA-15)
Sign In for Pricing
View Details