DHODH-IN-3

DHODH-IN-3 is a potent and selective inhibitor of human dihydroorotate dehydrogenase (HsDHODH), exhibiting an IC50 of 261 nM and binding with a Kiapp of 32 nM at the ubiquinone site. This compound shows promise as an antimalarial agent, supported by its activity in both enzymatic and cellular assays relevant to parasite proliferation.