DHODH-IN-8
DHODH-IN-8 is a potent dual inhibitor of both human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH), exhibiting antimalarial activity. It demonstrates potent inhibition with IC50 values of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM against the respective enzymes. This compound serves as a valuable chemical probe for researching malaria pathogenesis and DHODH-targeted therapies in both in vitro and in vivo models.
Product Specifications
CAS Number
1148126-03-7
Product Name Alternative
Plasmodium falciparum DHODH, human DHODH, DHODH, DHODH IN 8, DHODHIN8, DHODH-IN-8
Field of Research
Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology
Purity
99.57% (May vary between batches)
Solubility
DMSO:55 mg/mL (175.86 mM)
Smiles
ClC1=C (C2=CC=C (NC (/C (=C (/C) \O) /C#N) =O) C=C2) C=CC=C1
Molecular Formula
C17H13ClN2O2
Molecular Weight
312.75
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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