DO-264
DO-264 is a potent and selective inhibitor of the serine hydrolase ABHD12 (IC50 = 11 nM) . By blocking cellular lysophosphatidylserine (LysoPS) degradation, this compound enhances LPS-stimulated phagocytosis in vitro, making it a valuable tool for studying neuroimmunology and lysophospholipid signaling pathways.
Product Specifications
CAS Number
2301866-59-9
Product Name Alternative
DO 264, DO264, DO-264, ABHD12
Field of Research
Metabolism Research
Purity
97.72% (May vary between batches)
Solubility
DMSO:80 mg/mL (143.27 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.91 mM)
Smiles
FC (F) (F) Oc1ccc (Oc2ccnc (N3CCC (CC3) NC (=S) Nc3cccnc3) c2Cl) c (Cl) c1
Molecular Formula
C23H20Cl2F3N5O2S
Molecular Weight
558.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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