EGFR-IN-11
EGFR-IN-11 is a potent and selective EGFR tyrosine kinase inhibitor that induces apoptosis and causes G0/G1 phase cell cycle arrest. It demonstrates high potency against the resistant triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM. This compound is a valuable tool for in vitro research in non-small cell lung cancer and studies of acquired EGFR inhibitor resistance.
Product Specifications
CAS Number
2463200-44-2
Product Name Alternative
EGFR, EGFRIN11, EGFR-IN-11, EGFR IN 11, EGFRL858R/T790M/C797S
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.37% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.97 mM) ; DMSO:112.5 mg/mL (196.09 mM)
Smiles
CN1CCN (CC1) c1ccc (Nc2ncc3nc (Nc4ccccc4) n ([C@@H]4CCN (C4) S (=O) (=O) C4CC4) c3n2) cc1
Molecular Formula
C29H35N9O2S
Molecular Weight
573.71
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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