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EGFR-IN-2

EGFR-IN-2 is an orally bioavailable, mutation-selective EGFR inhibitor designed for NSCLC research. It potently targets T790M resistance mutants (IC50 27-33 nM) while sparing wild-type EGFR (IC50 218 nM) . This profile supports its investigation in preclinical models for overcoming tyrosine kinase inhibitor resistance.

Product Specifications

CAS Number

1643497-70-4

Product Name Alternative

EGFRIN2, EGFR, EGFR IN 2

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Purity

98.52% (May vary between batches)

Smiles

[C@@H] (CC) (C) N1N=C (C=2C1=CC (NC3=NC (=NC=C3) C4=CN (S (=O) (=O) C5CC5) N=C4) =NC2) N6CC (C (C) (C) O) C6

Molecular Formula

C26H33N9O3S

Molecular Weight

551.66

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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