EGFR-IN-5
EGFR-IN-5 is a potent and selective EGFR inhibitor with IC50 values of 10.4 nM (wild-type), 1.1 nM (L858R), 34 nM (L858R/T790M), and 7.2 nM (L858R/T790M/C797S) . This compound is a valuable research tool for studying EGFR-driven cancers in biochemical and cellular assays, aiding in the investigation of resistance mechanisms and therapeutic strategies.
Product Specifications
CAS Number
2225887-26-1
Product Name Alternative
HER1, Inhibitor, ErbB-1, Epidermal growth factor receptor, EGFR, EGFR (L858R), EGFR (L858R/T790M), EGFR (L858R/T790M/C797S), EGFR IN 5, EGFRIN5, EGFR-IN-5, EGFRL858R/T790M, EGFRL858R/T790M/C797S, EGFRL858R, inhibit
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
98.17% (May vary between batches)
Solubility
DMSO:120 mg/mL (209.9 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7 mM)
Smiles
N (C=1N=C (C2=C (N1) C=NC (NC3=CC=C (C=N3) N4CCC (N (C) C) CC4) =C2) N5CCC (CO) CC5) C6=CC=C (F) C=C6
Molecular Formula
C31H38FN9O
Molecular Weight
571.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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