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EGFR-IN-5

EGFR-IN-5 is a potent and selective EGFR inhibitor with IC50 values of 10.4 nM (wild-type), 1.1 nM (L858R), 34 nM (L858R/T790M), and 7.2 nM (L858R/T790M/C797S) . This compound is a valuable research tool for studying EGFR-driven cancers in biochemical and cellular assays, aiding in the investigation of resistance mechanisms and therapeutic strategies.

Product Specifications

CAS Number

2225887-26-1

Product Name Alternative

HER1, Inhibitor, ErbB-1, Epidermal growth factor receptor, EGFR, EGFR (L858R), EGFR (L858R/T790M), EGFR (L858R/T790M/C797S), EGFR IN 5, EGFRIN5, EGFR-IN-5, EGFRL858R/T790M, EGFRL858R/T790M/C797S, EGFRL858R, inhibit

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Purity

98.17% (May vary between batches)

Solubility

DMSO:120 mg/mL (209.9 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7 mM)

Smiles

N (C=1N=C (C2=C (N1) C=NC (NC3=CC=C (C=N3) N4CCC (N (C) C) CC4) =C2) N5CCC (CO) CC5) C6=CC=C (F) C=C6

Molecular Formula

C31H38FN9O

Molecular Weight

571.69

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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