EGFR-IN-9
EGFR-IN-9 is a potent and selective epidermal growth factor receptor (EGFR) kinase inhibitor, demonstrating IC50 values of 7 nM and 28 nM against wild-type and L858R/T790M mutant EGFR, respectively. This compound exhibits antitumor activity and is a valuable chemical probe for oncology research, supporting investigations into EGFR-driven cancers in both cellular and animal models.
Product Specifications
CAS Number
1226549-39-8
Product Name Alternative
EGFR (L858R/T790M), EGFR (wt), EGFR IN 9, EGFR (WT), EGFRL858R/T790M, EGFRIN9, EGFR-IN-9
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.46% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.93 mM) ; DMSO:90 mg/mL (188.87 mM)
Smiles
OC[C@@H] (Nc1ncnc2oc (c (-c3cccc (NC (=O) C=C) c3) c12) -c1ccccc1) c1ccccc1
Molecular Formula
C29H24N4O3
Molecular Weight
476.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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