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EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1 is a potent, orally bioavailable small molecule that selectively targets the EML4-ALK fusion oncoprotein with an IC50 of 1 nM. It is widely used in preclinical research to investigate ALK-driven non-small cell lung cancer (NSCLC) in both cellular assays and animal models.

Product Specifications

CAS Number

1373409-08-5

Product Name Alternative

EML4 ALK kinase inhibitor 1, EML4-​ALK kinase inhibitor 1, EML4-ALK, EML4-ALK kinase inhibitor 1

Field of Research

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Purity

99.14% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.61 mM) ; DMSO:99 mg/mL (170.47 mM)

Smiles

CCc1nc (C (N) =O) c (Nc2ccc (N3CCC (CC3) N3CCN (C) CC3) c (OC) c2) nc1N[C@H]1CC[C@@H] (CC1) OC

Molecular Formula

C31H48N8O3

Molecular Weight

580.76

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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