Exatecan
Exatecan (DX-8951f) is a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM, demonstrating antitumor activity. It is used in cancer research for in vitro cell line assays and in vivo animal models, as reported in preclinical studies on topoisomerase-targeted therapies.
Product Specifications
CAS Number
171335-80-1
Product Name Alternative
ADCCytotoxin, ADC Cytotoxin, DX8951, DX-8951f, DX 8951, Exatecan, Topoisomerase I, topoisomerase I
Field of Research
Molecular Biology, Pharmacology & Drug Discovery
Purity
99.64% (May vary between batches)
Solubility
DMSO:20 mg/mL (45.93 mM)
Smiles
N[C@@H]1C2=C3C (C=4N (C3) C (=O) C5=C (C4) [C@] (CC) (O) C (=O) OC5) =NC=6C2=C (CC1) C (C) =C (F) C6
Molecular Formula
C24H22FN3O4
Molecular Weight
435.45
Storage Conditions
-20°C
Notes
For research use only.
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