Forodesine hydrochloride
Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor, with IC50 values in the sub-nanomolar range across multiple species. It suppresses lymphocyte proliferation and induces apoptosis in leukemic cells by elevating intracellular dGTP levels, making it a valuable tool for oncology and immunology research in both in vitro and in vivo models.
Product Specifications
CAS Number
284490-13-7
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery
Smiles
Cl.OC[C@H]1N[C@H] ([C@H] (O) [C@@H]1O) c1c[nH]c2c1[nH]cnc2=O
Molecular Formula
C11H15ClN4O4
Molecular Weight
302.71
Storage Conditions
-20°C
Notes
For research use only.
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