GC 14

GC-14 is a potent and selective antagonist of human thyroid hormone receptors, demonstrating higher affinity for the hTRβ subtype (IC50 = 35 nM) than for hTRα (IC50 = 200 nM) . This small molecule is a valuable research tool for investigating thyroid hormone signaling in metabolic studies, cardiac function, and central nervous system research using both cellular and animal models.