GKI-1
GKI-1 is a potent and selective inhibitor of Greatwall kinase (GWL), demonstrating IC50 values of 4.9 μM and 2.5 μM against the full-length and kinase domain constructs, respectively. It exhibits stronger activity against ROCK1 (IC50 = 11 μM) and weak inhibition of PKA. This tool compound is useful for studying cell cycle regulation, mitosis, and PP2A-B55 phosphatase signaling in cellular and biochemical assays.
Product Specifications
CAS Number
2444764-03-6
Product Name Alternative
Greatwall (GWL), GKI-1, GKI 1, GKI1, hGWLFL, hGWL-KinDom
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.28% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.54 mM) ; DMSO:180 mg/mL (667.33 mM)
Smiles
N (C=1C=C (C=CC1) C=2C=NNC2) C3=CC=C (Cl) C=C3
Molecular Formula
C15H12ClN3
Molecular Weight
269.73
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
C5orf28 CRISPRa sgRNA lentivector (set of three targets)(Human)
