GNE-0439
GNE-0439 is a novel, state-dependent Nav1.7 inhibitor (IC50=0.34 μM) with significant selectivity over Nav1.5. Its unique carboxylic acid moiety binds outside the pore, differentiating it from VSD4-targeting compounds. This tool compound is valuable for in vitro electrophysiology and pain research to study sodium channel pharmacology and gating mechanisms.
Product Specifications
CAS Number
1241902-40-8
Product Name Alternative
Nav1.7, GNE0439, GNE-0439, GNE 0439
Field of Research
Pharmacology & Drug Discovery
Purity
99.60% (May vary between batches)
Solubility
DMSO:105 mg/mL (303.92 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:4 mg/mL (11.58 mM)
Smiles
C (N[C@@H] ([C@@H] (C) C) C (O) =O) (=O) C1=CC=C (C=C1) C2CCC (CCC) CC2
Molecular Formula
C21H31NO3
Molecular Weight
345.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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