GNE-987
GNE-987 is a potent chimeric BET degrader that binds with low nanomolar affinity to both BD1 and BD2 bromodomains of BRD4. It demonstrates picomolar cellular degradation activity and is a valuable chemical probe for oncology research, particularly in studying BET protein function in hematological cancers like AML, both in vitro and in vivo.
Product Specifications
CAS Number
2417371-71-0
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Purity
99.22% (May vary between batches)
Smiles
O=C1C2=C3C (C=4C (N (CC3=CN2) C5=C (F) C=C (F) C=N5) =CC (C (NCCCCCCCCCCC (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) [C@@] (C) (C) C) =O) =O) =C (CS (C) (=O) =O) C4) =CN1C
Molecular Formula
C56H67F2N9O8S2
Molecular Weight
1096.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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