INT-777
INT-777 (S-EMCA) is a potent TGR5 receptor agonist exhibiting an EC50 of 0.82 μM. It has been shown to suppress neuroinflammation by inhibiting the NLRP3-ASC inflammasome via the TGR5/cAMP/PKA pathway in rat models of subarachnoid hemorrhage, highlighting its utility in neuroscience and inflammation research.
Product Specifications
CAS Number
1199796-29-6
Product Name Alternative
INT 777, INT777, INT-777, S-EMCA, TGR5
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
99.38% (May vary between batches)
Solubility
DMSO:30 mg/mL (66.57 mM) ; Ethanol:50 mg/mL (110.95 mM)
Smiles
[H][C@@]12CC[C@H] ([C@H] (C) C[C@H] (C) C (O) =O) [C@@]1 (C) [C@@H] (O) C[C@@]1 ([H]) [C@@]2 ([H]) [C@H] (O) [C@H] (CC) [C@]2 ([H]) C[C@H] (O) CC[C@]12C
Molecular Formula
C27H46O5
Molecular Weight
450.65
Storage Conditions
-20°C
Notes
For research use only.
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