JAK3 covalent inhibitor-1
JAK3 Covalent Inhibitor-1 is a potent and selective small molecule inhibitor of Janus kinase 3 (JAK3) with an IC50 of 11 nM, showing 246-fold selectivity over other JAK family members. This compound is a valuable research tool for investigating JAK3-dependent signaling in immunological and inflammatory disease models, both in vitro and in vivo.
Product Specifications
CAS Number
2300106-50-5
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
N (C#N) [C@@H]1C=2C ([C@H] (NS (=O) (=O) C3=CC (F) =CC=C3) C1) =CC=C (C2) C4=C5C (=NC=N4) NC=C5
Molecular Formula
C22H17FN6O2S
Molecular Weight
448.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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