JBJ-02-112-05
JBJ-02-112-05 is an orally bioavailable, allosteric inhibitor that selectively targets mutant EGFR, specifically the L858R/T790M variant, with high potency (IC50 = 15 nM) . It is a valuable research tool for investigating resistance mechanisms in non-small cell lung cancer (NSCLC) in both cellular and animal models.
Product Specifications
CAS Number
2748162-29-8
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
C (C (NC1=NC=CS1) =O) (N2C (=O) C=3C (C2) =CC=C (C3) C=4C=C5C (=CC4) NC=C5) C6=CC=CC=C6
Molecular Formula
C27H20N4O2S
Molecular Weight
464.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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