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JI051

JI051 is a small molecule antitumor agent that targets the chaperone protein prohibitin 2 (PHB2) . Its mechanism involves suppressing Hes1 transcription, a key Notch pathway effector, leading to cell cycle arrest and inhibition of proliferation in HEK293 and pancreatic cancer cell lines in vitro.

Product Specifications

CAS Number

2234281-75-3

Product Name Alternative

Gammasecretase, Notch, JI 051, JI051, JI-051

Field of Research

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Purity

≥98% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.98 mM) ; DMSO:100 mg/mL (274.39 mM)

Smiles

CCOc1ccccc1CCNC (=O) \C=C\c1c[nH]c2c (OC) cccc12

Molecular Formula

C22H24N2O3

Molecular Weight

364.44

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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