JTE-952
JTE-952 is a potent, orally bioavailable, and selective Type II CSF-1R inhibitor (IC50=13 nM) with demonstrated efficacy in a mouse collagen-induced arthritis model. This small molecule is a valuable research tool for studying macrophage biology, inflammation, and autoimmune disease mechanisms in both in vitro and in vivo settings.
Product Specifications
CAS Number
1255303-54-8
Field of Research
Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (=O) (N1CC (C1) C2=CC (OC) =C (OCC3=CC=C (C=C3) C4CC4) C=C2) C5=CC (COC[C@H] (CO) O) =CC=N5
Molecular Formula
C30H34N2O6
Molecular Weight
518.6
Storage Conditions
-20°C
Notes
For research use only.
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