Iptacopan
Iptacopan (LNP023) is a potent and selective small molecule inhibitor of factor B, exhibiting high affinity with a KD of 7.9 nM and an IC50 of 10 nM. It is a valuable research tool for studying the alternative complement pathway in both in vitro assays and in vivo disease models, including paroxysmal nocturnal hemoglobinuria (PNH) .
Product Specifications
CAS Number
1644670-37-0
Product Name Alternative
Iptacopan, LNP 023, LNP023, LNP-023
Field of Research
Immunology & Inflammation
Purity
99.07% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.83 mM) ; DMSO:255 mg/mL (603.52 mM)
Smiles
CCO[C@H]1CCN (Cc2c (OC) cc (C) c3[nH]ccc23) [C@@H] (C1) c1ccc (cc1) C (O) =O
Molecular Formula
C25H30N2O4
Molecular Weight
422.52
Storage Conditions
-20°C
Notes
For research use only.
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