LY3020371 hydrochloride
LY3020371 hydrochloride is a potent and selective mGlu2/3 receptor antagonist, demonstrating antidepressant-like effects in vivo. It exhibits high affinity (Ki 2.5-5.3 nM) and blocks receptor-mediated cAMP formation (IC50 16.2 nM), making it a valuable tool for investigating mood disorders and glutamate signaling in both in vitro and in vivo research.
Product Specifications
CAS Number
1377615-44-5
Field of Research
Neuroscience
Smiles
Cl.[H][C@]12[C@H] (C (O) =O) [C@@]1 ([H]) [C@@] (N) ([C@H] (CSc1ccc (F) c (F) c1) [C@H]2O) C (O) =O
Molecular Formula
C15H16ClF2NO5S
Molecular Weight
395.81
Storage Conditions
-20°C
Notes
For research use only.
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