Mutated EGFR-IN-3
Mutated EGFR-IN-3 is a potent and selective allosteric inhibitor targeting EGFR mutations L858R/T790M and L858R/T790M/C797S, with IC50 values of 12 nM and 13 nM. This ATP-competitive dibenzodiazepinone is a valuable chemical probe for studying resistance mechanisms in non-small cell lung cancer (NSCLC) in biochemical and cellular assays.
Product Specifications
CAS Number
2375107-27-8
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C1C2=CC (OC3=CC=C (C=C3) N4CCN (C) CC4) =CC=C2NC5=CC=C (F) C=C5N1CC=6C=CC=CC6
Molecular Formula
C31H29FN4O2
Molecular Weight
508.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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