PF-04634817
PF-0463481 is a safe, orally bioavailable dual CCR2/CCR5 antagonist with potential for diabetic nephropathy research. It exhibits potent human and rodent CCR2 blockade (rat IC50=20.8 nM) and moderate rodent CCR5 activity (rat IC50=470 nM), supporting its use in both in vitro mechanistic studies and in vivo disease models.
Product Specifications
CAS Number
1228111-63-4
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Smiles
C (=O) ([C@]1 ([C@@H] (C) C) C[C@H] (N[C@@H]2[C@H] (OC) COCC2) CC1) N3[C@@]4 (CN ([C@] (C3) (C4) [H]) C=5C=C (C (F) (F) F) N=CN5) [H]
Molecular Formula
C25H36F3N5O3
Molecular Weight
511.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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