PIM447
PIM447 (LGH447) is an orally bioavailable, selective pan-PIM kinase inhibitor with demonstrated antitumor and bone-protective activity. It induces apoptosis and inhibits proliferation in hepatocellular carcinoma and multiple myeloma cell lines, supporting its use in oncology research for both in vitro and in vivo studies.
Product Specifications
CAS Number
1210608-43-7
Product Name Alternative
LGH 447, LGH447, LGH-447, PIM 447, PIM447, PIM-447
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
98.97% (May vary between batches)
Solubility
DMSO:80 mg/mL (181.63 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.35 mM)
Smiles
FC1=C (N=C (C (NC=2C (=CC=NC2) [C@@H]3C[C@H] (C) C[C@H] (N) C3) =O) C=C1) C4=C (F) C=CC=C4F
Molecular Formula
C24H23F3N4O
Molecular Weight
440.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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